In 1973, Iranian psychiatrist, E. Khorramzadeh, M.D., published the first report about the use of Ketamine in psychiatry in the Psychosomatic Journal. However, Dr. Khorramzadeh did not use Ketamine as an alternative alcoholism treatment. Instead, he administered Ketamine to 100 psychiatric patients with various psychosomatic diagnoses, including tension headaches, depression, anxiety, phobias, obsessive-compulsive neurosis, conversion reaction, hypochondriasis, hysteria, and ulcerative colitis.
Dr. Khorramzadeh reported that 91 of his patients were doing well after six months, and 88 of the subjects remained well after one year. Complications were minimal and included apprehension (2 subjects), nausea (3 subjects) and vomiting (2 subjects). Dr. Khorramzadeh concluded that Ketamine's “abreactive [cathartic] effect correlated well with Ketamine's mind-expanding effect
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